Module: Wrnap::Rna::Extensions::OneStructureBasedMethods

Defined in:
lib/wrnap/rna/extensions.rb

Instance Method Summary collapse

Instance Method Details

#base_pairs(structure) ⇒ Object 



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# File 'lib/wrnap/rna/extensions.rb', line 132

def base_pairs(structure)
  get_pairings(structure).each_with_index.inject(Set.new) do |set, (j, i)|
    j >= 0 ? set << Set[i, j] : set
  end
end

#collapsed_helices(structure, lonely_bp: false) ⇒ Object 



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# File 'lib/wrnap/rna/extensions.rb', line 128

def collapsed_helices(structure, lonely_bp: false)
  helices(structure).map { |((i, j), *rest)| Helix.new(i, j, rest.length + 1) }.select { |helix| lonely_bp ? helix : helix.length > 1 }
end

#get_pairings(structure) ⇒ Object 



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# File 'lib/wrnap/rna/extensions.rb', line 138

def get_pairings(structure)
	stack = []

  structure.each_char.each_with_index.inject(Array.new(structure.length, -1)) do |array, (symbol, index)|
	  array.tap do
	    case symbol
	    when "(" then stack.push(index)
	    when ")" then
	      if stack.empty?
	        raise "Too many ')' in '#{structure}'"
	      else
	        stack.pop.tap do |opening|
	          array[opening] = index
	          array[index]   = opening
	        end
	      end
	    end
	  end
	end.tap do
	  raise "Too many '(' in '#{structure}'" unless stack.empty?
	end
end

#helices(structure) ⇒ Object 



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# File 'lib/wrnap/rna/extensions.rb', line 118

def helices(structure)
  unless (array = base_pairs(structure).sort_by(&:first).map(&:to_a)).empty?
    array[1..-1].inject([[array.first]]) do |bins, (i, j)|
      bins.tap { bins[-1][-1] == [i - 1, j + 1] ? bins[-1] << [i, j] : bins << [[i, j]] }
    end
  else
    []
  end
end

#loop_regions(structure) ⇒ Object 



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# File 'lib/wrnap/rna/extensions.rb', line 109

def loop_regions(structure)
  [structure.split(//), (0...structure.length).to_a].transpose.select { |char, _| char == ?. }.inject([]) do |array, (_, index)|
    array.tap do
      matching_loop = array.map(&:last).each_with_index.find { |end_of_loop, _| end_of_loop + 1 == index }
      matching_loop ? array[matching_loop[-1]][-1] += 1 : array << [index, index]
    end
  end.map { |loop_indices| Loop.new(*loop_indices) }
end

#loops_and_helices(structure) ⇒ Object 



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# File 'lib/wrnap/rna/extensions.rb', line 105

def loops_and_helices(structure)
  [loop_regions(structure), collapsed_helices(structure, lonely_bp: true)]
end

#max_bp_distance(structure) ⇒ Object 



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# File 'lib/wrnap/rna/extensions.rb', line 101

def max_bp_distance(structure)
  base_pairs(structure).count + ((structure.length - 3) / 2.0).floor
end